Effects of ViralDefeat (SHL-V871) oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter 176 patient clinical trial Published March 3, 2021
Effects of ViralDefeat (SHL-V871) on patients with COVID-19
This trial provided direct evidence for the efficacy and safety for COVID-19 by using evidence-based medicine.
27 scientific authors and 10 institutions.
Patients in this clinical trial received antibody tests and CT scan to confirm the diagnosis.
For more than 17 years, a team led by Prof. Zuo (one of the co-authors of this paper) has studied the anti-viral effectiveness against SARS-coronavirus, MERS - Middle East respiratory syndrome coronavirus, and influenza virus (H1N1, H7N9, and H5N1), with symptoms of colds, sore throat, and cough with fever [11].
Is an effective broad-spectrum antiviral [12–15], which plays an important role in preventing and controlling the epidemic of SARS, Ebola hemorrhagic fever, influenza A, and avian influenza in China [15–18].
Based on such a standard treatment, the ViralDefeat groups showed several beneficial clinical outcomes compared with the control group, illustrating this effect treatment of patients with COVID-19.
Promoted the absorption of lung inflammation in the treatment group. Pneumonia is the major injury in patients with COVID-19.
Showed a beneficial trend on the hearts of patients with COVID-19. The levels of N-terminal brain natriuretic peptide (NT-proBNP) were numerically lower in the treatment groups on day 7 than that in the control group, with P value of 0.063. NT-proBNP is an important marker of heart failure.
The main mechanism to combat SARS-CoV-2 (COVID-19) is the ability to inhibit the enzymatic activity of the 3C-like protease (3CLpro) of the virus, which is essential for viral transcription and replication.
Considerable evidence has shown that inflammation storm plays an important role in the progress of COVID-19, additional studies indicated that baicalin could inhibit the expression levels of TNF-α, IL-6, and IL-8 in MRC5 cells induced by LPS [13,29,30] reducing inflammatory cytokines.
The study was approved by respective local ethics committees and performed according to the principles of the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice.
Company overview
Our advanced Nutraceutical and Pharmaceutical healthcare technologies are so sophisticated that we can deliver results without the side effects. We are very discerning in what products we bring to you and insist, they meet our renowned standards for significant value to human wellness. Our products hold patents, are patent pending or maintain Intellectual property requiring advanced manufacturing capabilities. We have developed superior expertise used by some of the largest corporations in the world. Our focus is unique proprietary products that lead the global wellness industry with quality and efficacy. Products that work! We’re one of the most innovative specialty companies in the world, manufacturing and marketing products to brand manufactures, government and institutional customers. We apply one global quality standard across our facilities and across our product line regardless of market.
Today, Nuumara innovations can be found in destinations across Canada, United States, Asia, Middle East and Gulf countries. Since its inception Nuumara aspires to be customer-centric and a leader in the global markets. Committed towards a healthier and happier world, we strive to provide accessible and affordable healthcare free from side effects.
Our Total Quality Management system adheres to and exceeds international regulatory standards and we endeavour to achieve and present the best quality in the industry. Our unique assets and skills are always oriented towards developing novel and differentiating scientific solutions through innovative products designed to improve the quality of life. Nuumara aspires to aid the global community through two parallel objectives: development and commercialization of medicines that deliver affordable and accessible treatment solutions to satisfy urgent medical needs.
Our values
PROUDLY CANADIAN, eh! Hockey, the maple leaf, grizzly bears, clean water, sub-zero winters......Canada is known for a lot of things; but in the world of advanced health care it is synonymous with reliability and world-class standards. At Nuumara, our Canadian culture and values drive everything we do. Here at home, we are recognized as an innovative leader. Our mission is to share those standards with the rest of the world, to become the best and most trusted innovation supplier in the business.
Innovation We are unconventional, visionary and bold. We “connect the dots” others overlook. We see possibilities and bring them to life. We love to challenge the status quo and introduce new and better ways to help people everywhere enjoy a higher quality of life. Having the courage to be a force for constructive change is in our DNA. Reliability Dependable. Reliable. Call it what you will, we've made it a habit. We strive to be there through thick and thin, rain or shine, delivering on every promise, every time. That's why people around the corner and across the world count on Nuumara. Service We understand that "it's not about us"—it's about helping others—and we believe there's no situation we can't handle. We would do whatever it takes to meet someone’s need. We wrap our high quality products in high quality service. Teamwork Together, we can run faster, reach higher and achieve more than any one of us can alone. We relish opportunities to collaborate because it’s invigorating, enlightening and powerful. When we join forces and plow through boundaries, we move mountains.
our strengths
GLOBAL REACH WITH A HUMAN TOUCH One of the things that set us apart in the industry is that we enjoy a global reach and influence while offering personal, hands-on service. To us, no two relationships are alike. That's why when you work with us, we really take the time to listen and understand your unique needs and goals. Our diverse and dedicated teams around the world bring a people-first approach to everything we do, believing that human relationships are just as important as the bottom line.
1. Culture The Company is opportunity-driven, responding to new ideas and developments with industrial discipline on the one hand and strategic flexibility on the other. 2. Integration The Company is integrated across the value chain – research, development or manufacturing leading to corresponding advantages in terms of cost, quality and logistics. 3. Spread The Company addresses opportunities across areas of human concern, Antiviral therapeutics, mental health, brain wellness, diabetes, immune health, anti-aging, respiratory and other wide-ranging medical problems, each of which is growing in size and scope. 4. Intellectual Capital The company has demonstrated a high retention of senior management professionals over the last 12 years, catalyzing relationships across all stakeholders with informed decision-making practices. 5. Research Research is fundamental to who we are and what we do. We are not generic versions of other products in the global market. 6. Alliances The company has long-standing strategic research alliances with several renown institutions translating into insights related to exceptional product development and unique marketing opportunities.
why nuumara
What sets Nuumara apart? Why should you partner with us instead of the others? Because we do things differently. We don't just think with the left side of our brain, the rational scientific side that allows us to develop and deliver top-tier products and services. We're also driven by the right side of our brain, the emotional side that fuels our human approach, ignites our creativity and innovation, and sparks our ability to find pioneering solutions.
CANADIAN STANDARDS YOU CAN TRUST As a Canadian Company, our clients and partners across the globe expect something more from us, and we make it our number one priority to deliver. True to our Canadian heritage, we are authentic, reliable and trustworthy. We develop and deliver to market products and services of the highest quality. We believe in doing things the right way. And when you're looking for a global provider of unique Pharmaceuticals and Nutraceuticals, that's exactly what you want. We strictly follow however exceed Good Manufacturing Practice requirements. We are also a certified USDA manufacturer, certified Organic, Kosher, Halal and cGMP, Health Canada certified and NSF certified.
COLLABORATION YOU CAN COUNT ON We believe it takes a whole lot more than offering world-class products to be successful in this business. We place just as much value on forging solid, lasting relationships. And that's why we've earned a solid reputation as a customer centred company. So how do we do it? By putting experts “on the ground” in the key markets as you need us. By being flexible and adaptable to your unique needs and goals. And by conducting ourselves with integrity, reliability and consistency you can count
YOUR LOCAL PARTNER WORLDWIDE Because we have experts in key markets across the globe, we can be wherever you are, whenever you need. When you collaborate with us, your challenges are our challenges. Your priorities are our priorities. And your success is our success. In your region, you need products that will put you on the map, keep you a step ahead. And that's where we come in. We deliver top-quality products ready for the specific and evolving health care needs. PARTNER WITH US Why is Nuumara the right fit for you? Because we provide unparalleled 360-degree service, giving you the tools and support you need for long term success in your market. With our own world-class research and exceptional manufacturing facilities including extensive supply and distribution experience, we deliver what you need, when you need them.
Announcements
I am delighted to announce that Nuumara has entered into a collaborative agreement in principle with one of the most respected and noted research institutions in Africa.
Our alliance involving plant-based medical research is a strategic initiative for us, and as partners our science and medical teams will engage and investigate various initiatives, applications and discoveries from a clinical perspective as it relates to its impact on human health.
We have an exceptional opportunity to not only discover and better understand the abundant array of active constituents found in Cannabis, but to equally explore the plethora of medicinal plants that have not garnered the kind of attention other regions have around the world, that are yet to be realized in the African Sub-Sahara.